Endocrine Abstracts

Background: Experimental and clinical studies have demonstrated that heritability of diabetes is associated with marked hyperinsulinemia, impaired endothelial function, and inflammatory up-regulation. However, no studies have examined whether a family history of diabetes effects placental maternal and fetal vascular circulation, or placental inflammatory response. The present study was designed to investigate the impact of first-degree family history of diabetes (FHD) on place...

Background: Obesity in pregnancy is associated with hyperinsulinemia, impaired endothelial function, inflammatory up-regulation and higher risk of placental pathological lesions. However not all obese individuals demonstrate similar metabolic profiles. The present study was designed to investigate placental histopathology in lesions that are associated with maternal and fetal circulation abnormalities, in nonobese and obese women with and without metabolic alterations.<p c...

Objective: The present study was designed to investigate the impact of insulin treatment on placental maternal and fetal vascular circulation in obese and non-obese women with gestational diabetes mellitus (GDM).Design and methods: One hundred and ninety two women with GDM who gave birth and underwent a placental histopathological examination at Wolfson Medical Center were included in the study: 123 women who were treated with diet (Group 1) and 69 women...